Pluripotent stem cells (PSCs) have the ability to give rise to all cell types found in the adult body. Our laboratory focuses on both studying their biology and using them for disease modeling.

With the support of the Armenise-Harvard foundation and the European Research Council we are characterizing the transcriptional and metabolic networks controlling the identity of PSCs.

In a second line of research, made possible by the Telethon foundation, we use PSCs to study the pathogenesis of neurodegenerative diseases, with the aim to identify genes involved in the cellular toxicity that could serve as potential therapeutic targets.